MODIFICATION OF DISSOLVING STUDIES OF GLİCLAZİDE IN LONG RELEASE TABLET FORM USING DIFFERENT POLYMERS

Kubra Kol*, Hakan Kızıltas, Taner Tekın and Gokay Gun

The main purpose of this study is to obtain an long release tablet formulation of gliclazide utilizing wet granulation production method after evaluation of different polymer structures. In order to provide the long release profile of the gliclazide, trial studies were carried out with xanthan gum, hydroxypropylmethylcellulose (HPMC K100M), povidone K30 and povidone K90 polymers, which have different viscosity properties. Dissolution rate (In vitro) test was applied to each trial run. In this study, Diamicron MR 60 mg Tablet was used as reference product for dissolution rate tests. As a result of dissolution rate (in vitro) studies, dissolution rate profile was obtained by plotting the dissolution amount of gliclazide versus time. To conclude, it was determined that the polymers providing long release of gliclazide were Povidone K30 and Povidone K90 mixture, and it was proved by the dissolution rate test.