SYNTHESIS AND IN VITRO ANTHELMINTIC ACTIVITY OF {3-[2-(5,6-DICHLORO-1H-BENZIMIDAZOL-2-YL)-2-OXOETHYL] PHENYL}ACETIC ACID AND ITS DERIVATIVES

Rohit Jaysing Bhor*, Shekhar Namdeo Kharde, Nayan Pandurang Shinde, Sonali Pawar, Shrutika Shantinath Vikhe

Introduction: The 6-membered benzene bonded to the five-membered imidazole molecule is the primary structural member of the benzimidazole group of heterocyclic, aromatic chemicals. The utilisation of substances with benzimidazole motifs in pharmaceutical and scientific research has showed potential. The goal of the study was to evaluate the pharmacological effects of synthetic compounds. For its anthelmintic characteristics, of AD derivatives were studied. This study set out to assess the pharmacological potency of synthesised drugs. The primary goal of this study is to create biodegradable benzimidazole derivatives by using catalyst. Benzoglyoxalines was also known as benzimidazoles. Methods: The structure confirmations of synthesized compounds were done by FTIR, NMR spectroscopy and MS. Results: According to the data, Al and AK give notable anthelmintic activity when compared to conventional medications like Albendazole. Conclusion: The in vitro anthelmintic activity of the title compounds and its derivatives was studied. Table 1 displays the findings of the produced compounds' initial in vitro anthelmintic activity testing.