IN-VITRO ANTI- DIABETIC POTENTIAL AND PHYTOCHEMICAL SCREENING OF DENDROBIUM MACRAEI LINDL.

Pushpa, *Dr. Esha Vatsa, Krati, Nidhi Chaudhary and Dr. Amandeep Singh

The rising global prevalence of diabetes mellitus has intensified the search for alternative and natural antidiabetic treatments. Dendrobium macraei a medicinal plant traditionally used in various cultures, has shown promising potential for managing diabetes. This study investigates the in vitro antidiabetic effects and phytochemical profile of Dendrobium macraei Lindl., with a particular focus on its alpha-amylase inhibitory activity. Preliminary phytochemical screening of the plant extract revealed the presence of several bioactive compounds, including glycosides, alkaloids, flavonoids, carbohydrates, proteins, steroids, and tannins. These compounds are known to contribute to the therapeutic effects of medicinal plants, including blood sugar regulation. In vitro assays demonstrated that the extract significantly inhibited alpha-amylase activity, a key enzyme involved in the breakdown of starch into glucose. By inhibiting alpha-amylase, the plant extract slows the rate at which glucose is absorbed, thus potentially reducing postprandial blood sugar spikes. Additionally, the plant extract enhanced insulin sensitivity and reduced glucose absorption, further supporting its potential as a natural antidiabetic agent. These findings highlight the potential of Dendrobium macraei Lindl. in the development of alternative diabetes treatments. The plant’s bioactive compounds, particularly those involved in alpha-amylase inhibition, could be beneficial in managing blood sugar levels and preventing complications associated with diabetes. Future research is required to fully understand the mechanisms of action and clinical applicability of Dendrobium macraei Lindl. in diabetes management.