DESIGN AND SYNTHESIS OF NOVEL HETEROCYCLIC DERIVATIVES AS POTENTIAL ANTI-CANCER AGENTS

Dr. Deepak Shrivastava*

Heterocyclic compounds have been recognized as pivotal scaffolds in the discovery of novel anti-cancer agents due to their diverse biological activities and structural versatility. In this study, novel heterocyclic derivatives were designed and synthesized using a rational drug design approach, targeting specific molecular pathways associated with cancer progression. The synthetic methodology involved multi-step reactions including condensation, cyclization, and functional group modifications. The synthesized compounds were characterized by spectroscopic techniques such as NMR, IR, and mass spectrometry. In vitro cytotoxicity assays against various human cancer cell lines revealed promising anti-proliferative activities, with several derivatives showing IC₅₀ values in the low micromolar range. The findings suggest that these novel heterocyclic derivatives hold potential as lead molecules for further optimization in anti-cancer drug development.