EFFECT OF ISOQUINOLINE ALKALOIDS – F-5, F-24, AND THEIR DERIVATIVES (KV-6, KV-8) ON THE FUNCTIONAL STATE OF LIVER MITOCHONDRIA IN RATS

Abduvali Abdubokiev*, Shunkor Khushmatov, Nurali Ergashev, Esohon Komilov, Sherzod Zhurakulov

In this study, it was found that flavonoid conjugates (KV-6, KV-8) of isoquinoline alkaloids (F-5, F-24) (5-20 μM) in an incubation medium with [Ca2+]out=10 mM depending on the concentration (5-20 μM) weaken the process of mitochondrial swelling in the liver of rats. In this case, it was confirmed that these agents at a maximum concentration of 20 μM reduce the swelling process by 47.40±2.32%, 41.86±3.07%, 62.20±3.17% and 56.84±2.24%, respectively, compared to the control. It was noted that this activity is manifested to a greater extent in their conjugates compared to isoquinoline alkaloids (F-5, F-24). The obtained results can be used as a scientific basis for the development of therapeutic drugs for the treatment of liver diseases based on isoquinoline alkaloids and their derivatives.