MANDAR AGADA AS AN ANTI-TOXIC FORMULATION: A CONCEPTUAL EXPLORATION

Dr. Dhanshree R. Pawar*, Dr. Rohit N. Pawar, Dr. Aniket Y. Joshi, Dr. Pooja G. Nagose, Dr. Nilofar A. Tamboli, Dr. Sonali R. Mali

Ayurveda is regarded as a distinctive medical system because it emphasizes addressing the root causes of disorders rather than merely managing symptoms. It teaches that disease arises when an individual loses awareness of their integral connection with the larger universe. In this tradition, the senses are employed both as preventive tools and as supportive elements, complementing herbal formulations and Panchakarma therapies. In his treatises Ashtanga Hridaya and Ashtanga Sangraha, Vagbhata provides detailed accounts of the origin of Visha and Keeta Visha. Among various forms of toxins, Keeta Visha is particularly significant due to its ability to produce intense clinical manifestations, which in some cases may even prove fatal. Managing these conditions is often difficult, as the identification of insect varieties remains unclear and regional differences lead to varied presentations. To counteract such effects, Acharya Vagbhata has described Mandar Agada, a classical preparation made from Vishaghna (anti-poisonous) herbs, specifically indicated for Keeta Chikitsa. Modern research suggests that the components of this formulation possess multiple actions, including anti-inflammatory, antimicrobial, antifungal, insecticidal, antioxidant, hepatoprotective, and immunostimulatory effects. The present review focuses on exploring the pharmacological and therapeutic aspects of Mandar Agada while emphasizing the antitoxic potential of its individual ingredients.