ROLE OF PROBIOTICS IN DIABETES MELLITUS

Sarojini Nayak*, Raghunandan Hota, Soumya Priyadarshi Behera, Priyanka Nayak

Diabetes has emerged as a predominant global epidemic, profoundly affecting both economic stability and individual health. Diabetes is linked to various problems, including obesity, hyperglycaemia, hypercholesterolaemia, dyslipidaemia, metabolic endotoxemia, intestinal barrier impairment, insulin secretion deficiencies, heightened oxidative stress, and chronic low-grade systemic inflammation. Diabetes is incurable; hence, contemporary research has concentrated on devising diverse strategies for diabetes management. Utilising probiotics is a viable technique for diabetes intervention. The pathophysiology of diabetes mellitus is intricate, involving variables such as oxidative stress and inflammation. Certain probiotics have been documented to diminish oxidative stress and inhibit the effector capabilities of CD4+ T cells while simultaneously lowering pro-inflammatory chemicals and exhibiting antioxidant, immunomodulatory, and antidiabetic properties. Moreover, probiotics may enhance the lipid profile, a primary risk factor for cardiovascular diseases (CVD), and may increase insulin sensitivity by mitigating systemic inflammation. This study consolidates information from scientific literature indicating that yoghurt is a functional food with potential antidiabetic and antioxidant effects. Interest in human microflora has lately emerged, demonstrating that it likely plays a significant role in maintaining metabolic homeostasis, and the administration of probiotics is a beneficial strategy for modulating human microbiota.