A SYSTEMATIC REVIEW OF Azadirachta indica FOR THE DEVELOPMENT OF AN IN-VITRO MODEL FOCUSING ON ALZHEIMER’S DISEASE

Dr. S. V. Rekha, Dr. Rajasekaran S., Fathima Rinsi C. P., Fathimathul Rinciya, Liya Balkkees K. V., Mohammed Sinan A. K.*

The study focuses on the A SYSTEMATIC REVIEW OF Azadirachta indica FOR THE DEVELOPMENT OF AN IN-VITRO MODEL FOCUSING ON ALZHEIMER’S DISEASE. Alzheimer’s disease is a progressive neurodegenerative disorder with limited effective treatments. Medicinal plants are being explored as alternative sources of neuroprotective agents. Azadirachta indica (Neem) is known for its antioxidant and anti-inflammatory properties, which may be beneficial in neurodegenerative conditions. This systematic review aims to analyze studies related to Azadirachta indica with relevance to Alzheimer’s disease, focusing on information useful for the development of an in-vitro model. Published literature was reviewed to identify experimental approaches, biological targets, and cellular responses associated with Alzheimer’s disease mechanisms. The review provides a structured summary of available evidence to support the design of in-vitro studies involving Azadirachta indica. This work may serve as a basic framework for future experimental research in Alzheimer’s disease.