THE ROLE OF NUTRACEUTICALS IN MANAGING METABOLIC SYNDROME: A REVIEW OF CLINICAL STUDIES

Prof. Abhishek Subhash Narwade*, Prof. Komal Ingle, S. Anjali Raju Deshmukh, S. Akanksha Balu Taksal, S. Sonal Tejrao Gawali, S. Rushikesh Gokul Tahakik, S. Shaikh Fazil Shaikh Mahamad

Metabolic syndrome is a cluster of interrelated conditions, including central obesity, insulin resistance, dyslipidemia, and hypertension, that significantly increase the risk of cardiovascular diseases and type 2 diabetes. In recent years, nutraceuticals have gained attention as complementary therapeutic agents due to their bioactive properties and favorable safety profiles. This review evaluates clinical studies investigating the role of nutraceuticals in managing metabolic syndrome.Evidence from randomized controlled trials and observational studies suggests that nutraceuticals such as omega-3 fatty acids, polyphenols, probiotics, vitamins, and plant-derived compounds can positively influence various components of metabolic syndrome. These bioactive substances have been shown to improve lipid profiles, enhance insulin sensitivity, reduce oxidative stress, and modulate inflammatory pathways. For instance, omega-3 fatty acids are associated with reduced triglyceride levels, while polyphenols and probiotics contribute to improved glycemic control and gut microbiota balance.Despite promising findings, variability in study design, dosage, and duration limits the generalizability of results. Additionally, the long-term safety and efficacy of nutraceutical interventions remain inadequately established. Nevertheless, the integration of nutraceuticals with lifestyle modifications, including diet and physical activity, may offer a holistic approach to managing metabolic syndrome.In conclusion, nutraceuticals present a potential adjunct strategy in the prevention and management of metabolic syndrome. Further large-scale, well-designed clinical trials are needed to establish standardized guidelines and confirm their therapeutic effectiveness.