PREPARATION AND EVALUATION OF ANTIFUNGAL CREAM OF AILANTHUS EXCELSA

Akash Kumar, Vinayak Dasharath Gaikwad*, Subhranshu Panda, Dinesh Kumar Upadhyay

Mahadung and Mahanimb are popular names for Ailanthus excelsa (Simaroubiaceae). The vast Ailanthus excelsa tree, which originated in China, is referred to as the "Tree of Heaven."It is used as an antispasmodic, bronchodilator, gout, rheumatism, dysentery, asthma, and bronchodilator. astringent, diabetes, cancer, appetizer colic pain, cough, and refrigerant. Additionally, the extract has strong antibacterial and antifungal properties and is used to treat wounds and skin eruptions. A mechanical grinder was used to powder the dried material. Maceration extraction will be used to remove the powder. Ethanol and water (hydroalcoholic 70:30) were the solvents employed. Alkaloids, terpenoids, flavonoids, and quassinoids are phytochemicals. Numerous recognized pharmacological actions, such as antifungal, anti-inflammatory, antibacterial, and antiasthmatic effects, are caused by these substances. Lecithin, cetostearyl alcohol, liquid paraffin, water, glycerine, methyl paraben, and propyl paraben extract were added in different amounts (e.g., 2%, 4%, 10%, 15%) to create a cream basis. Ailanthus excelsa extract was used in this work to formulate a herbal antifungal cream. To make sure the formulation was suitable for topical application, physicochemical characteristics including pH, appearance, viscosity, spreadability, and skin irritation potential were assessed.