A RESEARCH ON “FORMULATION AND EVALUATION OF TRANDERMAL PATCH OF ONDANSETRON HYDROCHLORIC ACID (HCL)”

Barsha Chaudhary *, Anjali Kumari Chaudhary, Idma Miya, Pratibha Ghimire, Kaish Ansari*, Pravez Alam

The primary theme of this research is to design the formulation and evaluation of a transdermal patch of Ondansetron hydrochloric acid (HCL), used in the prevention and management of chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PONV), radiotherapy as well as surgery through acting upon a serotonin receptor i.e. 5-HT (5-hydroxytryptamine) and subtype-3 (5-HT3) receptor as agonist. 5-HT3 receptors, located centrally in the chemoreceptor trigger zone of the area postrema as well as peripherally on vagal nerve terminals, are key receptors in the nausea and vomiting response. With the controlled release of this patch directly into the bloodstream and without liver metabolism, this approach provides therapeutic benefits with improved drug efficacy, bioavailability, cost effective, enhanced drug safety, easy and painless administration lead to increase in patient compliance compare to other doses form of drug. In this study, transdermal patch formulations were prepared containing different ratio of hydrophobic i.e. ethyl-cellulose (EC) and hydrophilic polymeric i.e. Hydroxypropyl methylcellulose (HPMC) systems using the Solvent Evaporation Method in 50:50 ratio of ethanol and water as solvent. All the formulated transdermal patches were tested using several physicochemical analyses, including changes in weight, thickness, drug content, and so forth.