World Journal of Pharmaceutical
Science and Research

An International Peer Reviewed Journal for Science & Pharmacy Professional


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ISSN: 2583-6579


Impact Factor: 3.454

ABSTRACT

FORMULATION AND EVALUATION OF TABLET OF NICARDIPINE HCL AS A SOLID SELF-EMULSIFYING DRUG DELIVERY SYSTEM

Miss. Snehal Somnath Gaware* and Prof. S. S. Gaikwad

Nicardipine HCl is an oral calcium channel blocker used to treat hypertension and heart failure, however it has poor oral solubility, stability, and bioavailability. This study's goal was to create and test a solid self-emulsifying drug delivery system for nicardipine HCl tablets that would increase the medication's solubility, stability, and oral bioavailability while using the least amount of surfactant feasible. Several solid SEDDS (S-SEDDS) formulations were also made using T4 (tablet). Tablets were made utilizing the Direct Compressional method with an improved SEDDS composition. [T4] In vitro release was also nearly similar for tablets of SEDDS that is, 35.18 % and 92.67 in 5 min and 30 min respectively. Increasing the drug's oral bioavailability (now between 35 and 40 percent) is also a primary objective. In summary, our research showed that the Direct Compressional methodology might be a practical way to make solid SEDDS tablets. When more cosurfactant was added to the mixture than surfactant, the microemulsion quality dropped dramatically. Compared to the other formulations, the microemulsion produced by the T4 formulation is the most stable upon dilution and has the best microemulsion penetration.

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