THE DESIGN AND BIOPHARMACEUTICAL EVALUATION OF NANOPARTICLES CONTAINING 5-FLUOROURACIL (5-FLUORO-H,3-H-PRIMIDINE2,4-DIONE)

*Raveendran K. C.

Cancer is a major public health concern in both developed and developing countries. Now a days, the treatments of cancer categorize in to 5 classes, Surgery, Radiation, Chemotherapy, targeted and immunotherapy. Cancer chemotherapy is one the major way to treat cancer without medical assistants. The main aim of the ideal cancer chemotherapy is to deliver the correct amount of drug with desired controlled rate and sufficiently longer duration of time to the site of action (Tumor cells) to obtain the desired therapeutic response. Traditional cancer chemotherapy is based on the promise that tumor cells are more likely to be killed by anticancer drugs because of the faster proliferation of those cancer cells. However, in reality most of the drugs cannot differentiate cancer cells from the normal cells. This results in the undesirable effect of the drug because of the lack of selectivity. To minimize this risk, the development of tumor targeted drug delivery systems of anti-cancerous agents is necessary. The success of therapy depends on the selection of ideal carriers’ system that can deliver the drug selectively to tumor cells. These carries include nanoparticles, nanotubes, nanorods, dendrimers, micelles, solid lipid nanoparticles, microspheres.