ASSESSING THE ASSOCIATION BETWEEN VITAMIN D3 DEFICIENCY, HOMA-IR, AND DIABETES PREVALENCE: A RETROSPECTIVE STUDY IN BAGHDAD HOSPITALS

Muna Ghafil Abed*, Ameer Qusay Abbas, Wisam Faris Abd Al_Ameer

Background: Diabetes mellitus is a significant global health burden characterized by high blood sugar levels due to insulin deficiency or resistance. Emerging research suggests a potential link between Vitamin D3 deficiency, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and diabetes prevalence. Aim: The purpose of this research was to investigate how lack of Vitamin D3, HOMA-IR, and the rate of diabetes are connected. This was done by studying information about the participants, their lab results, and any patterns found. Materials and Methods: We looked back at health records from several hospitals in Baghdad. We studied the data from 210 people, including 135 diagnosed with type 2 diabetes and 75 who didn’t have diabetes. We collected data about their age, gender, blood sugar levels after fasting, the percentage of sugar attached to their hemoglobin (HbA1C), insulin levels, and Vitamin D3 amounts. Results: The group with diabetes had noticeably higher levels of fasting blood sugar, HbA1C percentages, and insulin than the non-diabetic group. They also had less Vitamin D3. We saw clear links between HOMA-IR, fasting blood sugar levels, and HbA1C percentages in the diabetic group. In both groups, Vitamin D3 levels fell as HOMA-IR went up. Conclusion: This research gives us useful knowledge about how a lack of Vitamin D3, HOMA-IR, and the rate of diabetes are related. Regularly checking fasting blood sugar levels, HbA1C percentages, insulin levels, and Vitamin D3 could help us understand how the body deals with sugar and insulin resistance. Further prospective studies are needed to confirm these associations and explore underlying mechanisms. Understanding these relationships could contribute to more effective preventive strategies against metabolic disorders such as type 2 diabetes.