ABSTRACT
DEVELOPMENT OF ORAL DISPERSIBLE TABLETS (ODT) WITH A COMBINATION OF ACTIVE SUBSTANCES WITH HIGH AND LOW SOLUBILITY
Canberk Yılmaz*, Gokay Gun and Erdınc Babuc
Chlorhexidine HCl and Lidocaine HCl with antiseptic and analgesic effect of diseases that cause sore throat and irritation it is used in the symptomatic treatment. The aim of this study is to develop a lozenge product with a combination of active ingredients with high and low solubility contained in low amounts in the formulation, technology transfer processes were carried out. During the trial production, the development studies of Chlorhexidine HCl and Lidocaine HCl raw materials, which are present in low amounts in the formulation, with different production methods were described in detail.
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