A REVIEW ON BIOLOGICAL ACTIVITIES OF COUMARIN DERIVATIVES

Sarah A. Hameed*, Manal Hatem Ahmed, Diyar Adel Lateef

Coumarins, which are derived from plants, encompass a wide range of structurally diverse natural substances that exhibit various bioactivities. The aim of this paper is to present an introduction to coumarins and their applications as medicinal agents. Coumarin, a heterocyclic compound formed by the fusion of a benzene ring and a pyrone ring containing oxygen, and its derivatives are widely recognized due to their diverse biological activity and clinical applications. These compounds are highly effective in terms of their inhibitory activity and favorable selectivity ratio. Coumarins are considered a promising category of bioactive heterocyclic compounds that demonstrate a multitude of biological activities, such as antimicrobial, antiviral, antidiabetic, anticancer, antioxidant, antiparasitic, anthelmintic, antiproliferative, anticonvulsant, anti-inflammatory, and antihypertensive activities, among others. The information provided in this manuscript could potentially aid in further research on the development of improved antimicrobial agents with reduced microbial resistance and enhanced antimicrobial profile.