EFFECT OF OBESITY ON SOME SERUM ANTIOXIDANT PARAMETERS IN SAMPLE OF IRAQI MEN ≥ 40 YEAR

Mustafa Salim Ibrahim*, Ziad Hammad Abd

Background: Obesity is an unhealthy condition that is considered a major condition due to its epidemic commonness many of which are also associated with many comorbidities. Obesity is not only weight gain, but it is seen as a state of metabolic dysfunction that results from the accumulation of remaining or excess calories from food in visceral fat, and thus many concentrations of free fatty acids are released in several parts of the body. This is considered a state of chronic oxidative stress. Aim: Body Mass Index (BMI) correlation was the goal of this investigation. With some serum antioxidants including enzymatic (Glutathione reductase (GR), Superoxide dismutase (SOD), and non-enzymatic (Glutathione (GSH) and Vitamin C (Vit-C)). Material and methods: There were 127 apparently healthy Iraqi men participating in this investigation. Ages 40 to 79 made up their group, and their body mass index also ranged from (18-39.9) kg/m2. GR, SOD, GSH, and Vit-C in serum were analyzed by colorimetric methods. Results: Men had a mean BMI of (29.308±4.77) kg/m2. Four BMI categories for the men were created, including: There are no men underweight, 26 men (20.47%) were of normal BMI, other 47 men (37%), 33 cases (25.98%), and 21 case (16.53%) were overweight, obese, and morbidly obesity respectively. The mean of serum parameters GR, SOD, GSH, and Vit-C in all men under study were (mean ± SD) (39.469±9.602 U/l), (1.836±0.466 U/l), (4.240±1.312 μmol/l), and (1.427±0.303 mg/l) respectively. In Iraqi men, a higher BMI was substantially related with a decline in S.SOD and S.Vit-C, but not with a relationship between BMI, S.GR, and S.GSH (P 0.05). Conclusions: Men who have a higher body mass index are more liable to oxidant stress.