FORMULATION AND EVALUATION OF ANTIFUNGAL CREAM OF GRAPE SEEDS EXTRACT AND POMEGRANATE FRUIT EXTRACT

*Wattamwar P. B., Muttinpende M.V., Nelwade V. R., Murudkar R. R., Natkar M. G. Naiwade P. S.

Fungal infections are of serious public health concern. The incidence of fungal infections in patients with other diseases including Covid-19 is associated with life threatening mycoses and mortality. Oxygen uptake while breathing cause‟s free radical production and in addition to that environmental factors such as pollutants, smoke and certain chemicals also contribute to their formation. Antioxidant is any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate. Pomegranate is a potent antioxidant. This fruit is rich in flavonoids, anthocyanins, punicic acid, ellagitannins, alkaloids, fructose, sucrose, glucose, simple organic acids. The antioxidant property of proanthocyanidin is because of the availability of the phenolic-hydrogens as singlet oxygen quenchers and hydrogen donating radical scavengers. Creams having less adverse effect than dosage form.