FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF POSACONAZOLE LOADED TRANSFEROSOMES GEL

Amulya Chikoti and Jimidi Bhaskar*

The goal of the current research was to create Posaconazole (PSZ) transferosome gel that would be effective against fungal infections. The gel was created by thin film hydration method. A study of the interactions between drugs and excipients was then conducted using the Fourier transform infrared (FTIR) spectroscopy method. The formulations were prepared and evaluated for measurement of pH, viscosity, spreadability, % entrapment efficiency, drug content estimation and in vitro diffusion study. Eight formulations were developed(PF1-PF8). In a Franz's diffusion cell, in vitro diffusion studies were carried out. The PF7 batch demonstrated the highest drug release after 24 hours. The developed formulation was stable, non irritant and provided sustained release over 24 hrs.