PREPARATION AND EVALUCATION OF FAST DISINTEGRATION TABLETS OF POSACONAZOLE

G. Rahul, J. Yashashwini, K. Vikram, K. Ujwala, K. Sai Rupini, *Dr. Jimidi Bhakar and Dr. Reddy Nazemoon

Posaconazole is a broad spectrum triazole antifungal agent with potent activity against various fungi, including yeast and moulds Clinical studies have demonstrated that the agent is efficacious as prophylaxis against inventive fungal infections inpatients at hedonist and may also useful in salvage therapy against invasive aspergillosis and mucomycosis However, the bioavailability Posaconazole following administration as oral suspension, which was the only formulation clinically available for many years variable negatively influenced several factors because many by the patients had sub therapeutic levels when the oral suspension was wed, overcome this limitation delayed release tablet was developed and is now available for clinical use. In addition, pharmacokinetic parameters following administration of the tablets were not Significantly affected by medication that increasing gastric motility, and the tablets could also be administrated without regard to food similar results have been found in patients at high risk for invasive fungal who have received.