TECHNOLOGY OF PREPARATION OF MICROENCAPSULATED FORMS FOR SUSTAINED RELEASE USING BIODEGRADABLE POLY LACTIC-CO-GLYCOLIC ACID (PLGA) POLYMER– REVIEW

Aleksey Poko*, Gokay Gun and Erdinc Babuc

Sustained-release drug-loaded microspheres provide a prolonged and precise delivery of medications combined with other advantageous effects. These microspheres are available in several varieties and may be synthesized using numerous techniques, which are reasonably straightforward to execute. Consequently, they have garnered considerable interest and are widely employed in tissue engineering and other associated disciplines. The aim of this review article is to offer a thorough and up-to-date examination of the essential understanding and present state of PLGA biodegradable microspheres. This work contains a discussion of the properties, pharmacokinetics and pharmacodynamics of the PLGA matrix material. In addition, the report outlines the several techniques used to prepare PLGA microspheres, including emulsification, microfluidic technology, electrospray, and spray drying.