HERBAL DRUG INTERACTIONS AND THEIR IMPACT ON PHARMACOKINETICS

J. Lakshmi Prasanna*, M. Jaya Shanti, K. Sowjanya and S. K. Hanisha

Herb–drug interactions are important issue for clinical therapeutic efficacy of medicine treatment. Herb–drug interactions affect either the pharmacokinetic fates or pharmacodynamics activities of drugs, leading to therapeutic failure or toxicities Unlike conventional drugs, herbal products are not regulated for purity and potency. Thus, some of the adverse effects and drug interactions reported for herbal products could be caused by impurities (e.g., allergens, pollen and spores) or batch-to-batch variability Pharmacokinetic interaction occurs when herbal drugs inhibit or decrease the normal activity level of drug transporters through a competitive or non-competitive mechanism. Interactions can also occur through the induction of transport proteins via the increase of the mRNA of the relevant protein. In this we have highlighted about the causes of herbal drug interactions and their article mechanisms with examples.