EFFECT OF TAMSULOSIN IN A MODEL OF ADENINE-INDUCED CHRONIC RENAL DISEASE

Mariana Cecilia Pérez-Villalobos, Nicté García-Carrillo, Andrea Barba-González, Martín Humberto Muñoz-Ortega, Esperanza Sánchez-Alemán, Manuel Enrique Ávila-Blanco, Jorge Christopher Morones-Gamboa, Javier Ventura-Juárez*, Sandra Luz Martínez-Hernández*

Chronic kidney disease (CKD) encompasses a spectrum of structural and functional abnormalities in the kidneys, persisting for over three months with specific health implications. It is estimated to affect 10% of the global population. These include morphological changes based on the combined responses of glomeruli, renal tubules, renal blood vessels, and/or renal interstitium to continuous injury, leading to chronic inflammatory processes and renal fibrosis. While no specific treatment has been established, angiotensin-converting enzyme inhibitors, their receptor blockers to regulate blood pressure, metabolic modulators to reduce hyperglycaemia, and statins to lower fatty acids have been utilized. The aim of this study was to analyze the effect of tamsulosin on an adenine-induced chronic kidney disease model in rats.