DESIGNING A LIPID-BASED FLOATING BEAD FOR PROLONGED RELEASE OF DEXTROMETHORPHAN HYDROBROMIDE

Rohit Rana Angral* and Monika Bansal

This study explores the potential of lipid-based floating beads to prolong the gastric retention and sustained release of DXM HBr, offering a novel approach to enhance its therapeutic profile and patient adherence. Lipid-based floating beads are designed to leverage the buoyancy of lipid components, allowing them to float in the stomach and extend the absorption window for drugs absorbed in the upper gastrointestinal tract. This study aimed to create and evaluate these beads to facilitate the sustained release of DXM HBr. The selection of lipid materials, including glyceryl monostearate and beeswax, was based on their compatibility with DXM HBr and their physicochemical properties. The preparation involved melting the lipid components, dissolving DXM HBr in a suitable solvent, and emulsifying the mixture under high shear conditions in an aqueous phase containing a stabilizer like polyvinyl alcohol. The resulting beads were then collected, washed, and dried.