FORMULATION & EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM FOR THE MANAGEMENT OF PAIN

Sakshi Trivedi*, Shubham Verma, Sobhna Singh

Microsponges are unique dermatological delivery techniques that can entrap actives 3 times their weight. The microsponge drug delivery system (MDS) releases its active ingredient on time and in reaction to rubbing, temperature, and pH when given by topical route. The particles or surfaces of microsponges include several active components. Each non-collapsible microsphere has many interconnected gaps to absorb material like a sponge. Porous outer surfaces govern material flow into and out of the sphere. Nimesulide is known as "non-steroidal anti-inflammatory drug. "As an analgesic and antipyretic, it reduces mild to moderate pain, fever, and inflammation. When used topically, nemesulide-loaded microsponges outperform conventional drug powder for inflammation in that they function more effectively and mitigate negative effects. The main objective of this study to formulate and evaluate the nimesulide microsponges by using various drug plymer (ethyl cellulose) ratio. We used simple, reproducible, and quick quasi-emulsion solvent diffusion to formulate the microsponge. After formulation, the microsponges were analyzed for their physical appearance, production yield, drug loading efficiency, particle size distribution, in vitro drug release, kinetics of drug release, scanning electron microscopy, and optical microscopy for particle size characterization. Controlled medication delivery via polymer-based systems is expected to be prevalent in the future due to its scientific and economic benefits. To reduce application frequency, hypersensitivity reactions, and safety over conventional formulation, polymeric microsponge delivery system distributed nimesulide continuously for a long time.