World Journal of Pharmaceutical
Science and Research

An International Peer Reviewed Journal for Science & Pharmacy Professional


Login | Registration


ISSN: 2583-6579


Impact Factor: 5.111

ABSTRACT

TREATING CARBAPENEM-RESISTANT ENTEROBACTERALES INFECTIONS: SIGNIFICANCE OF COMBINING CEFTAZIDIME-AVIBACTAM WITH AZTREONAM IN INDIAN SCENARIO

Dr. Sreevalsan T. V.* and Dr. Rohitha S. Chandra

In Indian ICUs, carbapenem resistance is seen among a significant proportion of Gram-negative infections. In India, NDM and OXA-48 enzymes are the predominant carbapenemases unlike the Western countries where KPC is the commonest. As the MBLs including NDM are not inhibited by Avibactam, Ceftazidme- Avibactam (CAZ-AVI) will be of limited use in India. As Aztreonam (ATM) is not hydrolyzed by the NDM, combining it with CAZ-AVI can be effective in this context. This single centre retrospective study aimed to find out the susceptibility of CRE isolates to CAZ-AVI and the usefulness of combining it with ATM to treat CRE resistant to CAZ-AVI. 294 CRE isolates were tested from 30 May 2022 to 30 July 2023. Susceptibility to CZA-AVI, ATM was studied. Synergy of the combination of the two among the isolates resistant to CAZ-AVI was also studied. It was found that Klebsiella pneumoniae was the most common CRE. 56.12% of the CRE isolates were resistant individually to CAZ-AVI and ATM. However, 83% of these isolates were found to be sensitive on synergy testing. This pattern is suggestive of the presence of NDM along with OXA-48 among CREs as reported by other Indian studies. Since Ceftazidime-Avibactam as a monotherapy for CREs will likely result in clinical failure, susceptibility testing with CAZ-AVI and synergy testing with ATM should be used to guide the treatment of CRE infections.

[Full Text Article]

TRACK ARTICLE

NEWS

  • Impact Factor Increased

    We are pleased to inform you that our IMPACT FACTOR has increased from 3.454 to 5.111

    Email & SMS Alert

    We will provide you email alerts regarding New Issue Release, Publication of your Article, Invitaion for New Upcoming Issue, Manuscript releted Emails etc.

    August 2024 Issue Published

    Its Our pleasure to inform you that, WJPSR August 2024 Issue has been Published, Kindly check it on Click here

    Indexing

    This journal is indexed in world wide reputed commettee like: "DOI for all Articles" "Google Scholer" "SJIF Impact Factor:- 5.111" "Cosmos Impact Factor" "ISI Indexing" "International Impact Factor Services (IIFS)" "ResearchBib" etc.

    Article Invite for Publication

    Dear Researcher, Article Invited for Publication  in WJPSR Coming Issue.

    If you wish to Publish your Article in WJPSR Coming" August 2024 " Issue, 

    Submit it as soon as possible.