World Journal of Pharmaceutical
Science and Research

An International Peer Reviewed Journal for Science & Pharmacy Professional


Login | Registration


ISSN: 2583-6579


Impact Factor: 5.111

ABSTRACT

ANTRODIA CAMPHORATA GROWN ON GERMINATED BROWN RICE INHIBITS HUMAN HEPATIC CARCINOMA CELLS PPROLIFERATION VIA G0/G1 CELL CYCLE ARREST AND APOPTOSIS INDUCTION

Mohammad Lalmoddin Mollah* and Maznah Ismail

Antrodia camphorata (A. camphorata) is a parasitic fungus that has been used in traditional Chinese medicine because of its wide range of pharmacological activities. The purpose of this study is to investigate the antiproliferative effect and the mechanism of the ethyl acetate extract from A. camphorata grown on germinated brown rice (AGBR-EtoAc) in human hepatic carcinoma HepG2 cell lines. The results show that AGBR-EtoAc has significant remarkable inhibitory and antiproliferative effects on HepG2 cells in a concentration and time dependent manner. AGBR-EtoAc involved in the regulation of G0/G1 cell-cycle arrest and induced cell apoptosis. The protein levels of Cdk4 and cyclin D1 in the AGBR-EtoAc treated group were lower than those in the control group. Also, the expressions of the p53 and Bax were increased and Bcl-2 protein was downregulated with AGBR-EtoAc treatment. These findings suggest that AGBR-EtoAc extracts might act as an effective anti-proliferative agent by inducing G0/G1 cell cycle arrest and involved cell apoptosis in hepatic carcinoma cells.

[Full Text Article]

TRACK ARTICLE

NEWS

  • Impact Factor Increased

    We are pleased to inform you that our IMPACT FACTOR has increased from 3.454 to 5.111

    Email & SMS Alert

    We will provide you email alerts regarding New Issue Release, Publication of your Article, Invitaion for New Upcoming Issue, Manuscript releted Emails etc.

    August 2024 Issue Published

    Its Our pleasure to inform you that, WJPSR August 2024 Issue has been Published, Kindly check it on Click here

    Indexing

    This journal is indexed in world wide reputed commettee like: "DOI for all Articles" "Google Scholer" "SJIF Impact Factor:- 5.111" "Cosmos Impact Factor" "ISI Indexing" "International Impact Factor Services (IIFS)" "ResearchBib" etc.

    Article Invite for Publication

    Dear Researcher, Article Invited for Publication  in WJPSR Coming Issue.

    If you wish to Publish your Article in WJPSR Coming" August 2024 " Issue, 

    Submit it as soon as possible.