PRODUCTION OF CREAM PREPARATION CONTAINING RUXOLITINIB PHOSPHATE ACTIVE INGREDIENT WITH WATER IN OIL SYSTEM

Seyma Gunes*, Sulenur Ekmekcı, Cuneyt Toprak, Gokay Gun and Erdınc Babuc

The aim of this study was to develop a formulation of a topical cream dosage form containing the active ingredient ruxolitinib phosphate, which is used effectively in non-segmental vitiligo disorders by specifically blocking JAK1 and JAK2, two enzymes involved in various cytokine pathways that contribute to inflammation, pruritus and skin barrier function in the skin, using the water in oil system within the scope of the patent overrun study. The present study describes the formulation, manufacturing method and the optimized formulation and manufacturing process of the Opzelura Cream product containing the active ingredient Ruxolitinib Phosphate, which has the targeted specification features, with the water in oil system, which is the reverse process of the oil in water system specified in the formulation patent number EP2574168B9.