DESIGN, SYNTHESIS, AND BIOLOGICAL PROPERTIES OF NEW 1,2,4-TRIAZOLE DERIVATIVES

*Prytula R. L., Parchenko V. V., Bushuyeva I. V., Yerenko O. K. and Khortetska T. V.

For a long time, derivatives of 1,2,4-triazole have attracted the attention of scientists worldwide. Their unique and valuable properties provide researchers with information on the practically limitless possibilities for discovering new promising molecules. The biological potential of 1,2,4-triazole derivatives is also well-known and is not limited to antifungal and antimicrobial properties. Many new types of pharmacological activity of substituted 1,2,4-triazoles have been discovered and studied by scientists over the past ten years. Regarding the general methods of synthesizing 1,2,4-triazole derivatives, they are well-known and widely used among organic chemists in the process of creating new unique molecules. The gradual, predicted introduction of different substituents into the 1,2,4-triazole derivative molecules leads to the appearance of new types of biological activity, and in some cases, this increases the activity levels already observed. Chemical modification of the compounds by altering substituents around the 1,2,4-triazole fragment fundamentally changes the type of biological activity of the new molecules. Despite the constant criticism of synthetic drugs, their role in healthcare cannot be overestimated. The ability to continuously improve synthetic molecules makes original drugs more effective and keeps them in high demand. The scientific school of Zaporizhzhia State Medical University has synthesized a significant number of 1,2,4-triazole derivatives[7–11] and developed various methods for their heterocyclization. The current scientific potential of new 1,2,4-triazole derivatives has been analyzed. The new compounds have proven to be promising biologically active agents. The wide possibilities for their application create favorable conditions for further research into new molecules based on 1,2,4-triazole.