A REVIEW OF THE ANALYSIS OF ANTIHISTAMINE MEDICATION FLOATING TIMES FOR EFFICIENCY EVALUATION

Mohammad Rafivulla, Darisi Saketh, Chowtipalli Pushpanjali, Gangolu Yohan, Gajula Meghamala, Rama Rao Vadapalli*

The purpose of a gastroretentive drug delivery system (GRDDS) is to increase drug absorption and bioavailability by extending the period of time that pharmaceuticals are in the stomach. This technique is especially helpful for medications with upper absorption windows digestive system or those that break down in the stomach's acidic environment. GRDDS can decrease dosage frequency and enhance therapeutic effects by prolonging a drug's gastrointestinal half-life.This review demonstrates a correlation between diminishing floating capabilities and the stomach residence time of antihistamine medications. For stomach residence and sustained release, two crucial variables are needed: total floating time and floating lag time. Among all antihistamine medications, Fexofenadine is notable for having the longest floating duration (>24 hours) and the shortest floating lag time (12.3 sec).These results suggest that among the formulations examined, Fexofenadine has the longest sustained release capacity and the best stomach residence time.