CUBOSOMES- AN EMERGING PLATFORM FOR DRUG DELIVERY

Avril Mathias* and Monika R.

Due to their unique properties and wide variety of applications, cubosomes—nanoscale cubic liquid crystalline formulations—have garnered a lot of attention recently. Self-assembling cubic phase nanoparticles are created when lipid molecules arrange themselves in a three-dimensional cubic lattice. These self-assembled nanoparticles have a large surface area and excellent stability due to their well-defined cubic lattice structures and amphiphilic surfactant composition. They are appealing choices for gene therapy, drug delivery, and other biological applications due to their special properties, which include their ability to encapsulate molecules that are both hydrophilic and hydrophobic. Presenting a comprehensive overview of the latest advancements in cubosome research, including their structural characterisation, synthesis methods, and functional applications, is the aim of this work. Among the key topics covered are the many methods for creating cubosomes, the manner in which lipid content influences their structural properties, and the mechanisms underlying their drug release profiles. Additionally, it will examine the difficulties and potential paths forward in refining cubosome formulations for enhanced clinical efficacy.