MECHANISM OF ENDOTHELIUM-DEPENDENT ACTION OF LEONURUS TURKESTANICUS EXTRACT

*Omonturdiev S.Z., Ismailova Sh.N., Inomjanov D.R., Abdullaev A.A., Abdullaev I.Z., Abduazimova D.Sh., Gayibov U.G., Saidbaeva L.M., Aripov T. F.

This article investigates the endothelial-dependent mechanism of action of Leonurus extract. The research demonstrates that the extract effectively influences aortic preparations even in the absence of the endothelial layer. These findings are supported by experiments using the eNOS inhibitor L-NAME, which serve as crucial evidence in understanding the role of the endothelium. The results provide a scientific foundation for exploring endothelial-mediated physiological processes and assessing the vasodilatory effects of the extract. The efficiency of the extract in modulating endothelial responses is noted to be linked to its influence on nitric oxide production processes mediated by the eNOS enzyme.