FORMULATION AND EVALUATION OF DOMPERIDONE CHEWABLE TABLETS

Satheesh Kumar P.*, Sakthi N., Sakthivel M., Sangeetha E. and Sankar S.

Chewable tablets have an advantage over conventional tablets as well as liquid dosage forms in geriatric and paediatric patients. They enhance both the therapeutic efficacy and the bioavailability. Domperidone chewable tablets were formulated so that compliance in the drug in children is achieved by improving the solubility and dissolution. Domperidone chewable tablets were prepared by employing wet granulation. Examination of the tablets was undertaken about general appearance, size, shape, color, odor, taste, hardness, friability, weight variation, disintegration, and content uniformity. The key is dissolution testing to discover any physical change in an API and in the developed formulation. Mechanism of action and some tablet-making defects, for example capping, lamination, picking, sticking, and mottling, are discussed under the root cause of the problems. Examples of some chipped or edged product forms are antacids, aspirin for kids, and chewable vitamins.