A REVIEW ON ANTICANCER ARMAMENTARIUM

Nidhi Jagtap, Shital J. Patil*

As one of the biggest causes of death globally, cancer requires the development of efficient treatment approaches. This article offers a thorough analysis of the anticancer properties of several synthetic and natural substances, with an emphasis on paclitaxel, docetaxel, resveratrol, glycyrrhizas acid, and abraxane. These substances show a variety of modes of action, such as the stability of microtubules, the induction of apoptosis, and the modification of signalling pathways, which makes them attractive candidates for cancer treatment. Plant-derived paclitaxel and its abraxane nanoparticle formulation have shown impressive effectiveness against a variety of solid tumors, including lung, ovarian, and breast malignancies. Glycirrhizic acid, a triterpene saponin from liquorice root, has demonstrated potential as a chemotherapy adjuvant by sensitizing cancer cells to chemotherapeutic agents and conquering drug resistance. Resveratrol, a naturally occurring polyphenol found in grapes and berries, has also demonstrated chemo preventive and chemotherapeutic properties. These chemicals have limitations, such as low bioavailability, safety issues, and drug resistance, despite their potential anticancer properties. Future studies should concentrate on creating tailored drug delivery systems, investigating therapeutic combinations that work well together, and carrying out efficacious and safe clinical trials. This review emphasizes the compounds' potential as effective anticancer medicines and stresses the need for more study in this area. In the battle against cancer, interdisciplinary teams and translational research are essential to realizing these substances' full potential and enhancing patient outcomes.