CHROMATOGRAPHIC MASS SPECTROMETRIC ANALYSIS AND IN-SILICO SCREENING FOR ANTI-DIABETIC ACTION OF SIGNIFICANT PHYTOCHEMICALS IN THE ALCOHOLIC EXTRACT OF Morinda Citrifolia. L

Dr. Thomas Kurian*, Dr. Rani Sebastian

An endocrine condition that deteriorates over time, diabetes mellitus can cause significant health problems, including heart, kidney, eye, and nerve issues. The majority of oral anti-diabetic medications are made of synthetic chemicals and have potential negative effects after extended use. With fewer adverse effects, phytochemicals with anti-diabetic properties are becoming more and more significant in anti-diabetic treatment. An attempt was made to identify the main phytochemicals from the ethanolic extract of the Morinda Citrifolia L, also known as the Noni plant. The main phytocompounds identified by GCMS were n-Tridecanoic acid, n-Decanoic acid, Methyl Hexadecanoate, N-(3,4,5,6-tetrahydroxy-1-nitrohexan-2-yl) acetamide, and Hexaldehyde. The phytocompounds were analyzed in-silico using PyRX docking with the auto dock Vina tool. The human SGLT2-MAP17 complex bound with empagliflozin PDBID 7VSI receptor was selected to dock ligands. The standard drugs used to validate the processes were empagliflozin (-10.7) and sotagliflozin (-7.5). Potential candidates were selected for further investigation by comparing (N-(3,4,5,6-tetrahydroxy-1-nitrohexan-2-yl) acetamide) (-6.8), methyl hexadecanoate (-6.5), and n-Tridecanoic acid (-6.2). The Swiss-ADME settings were suitable. They followed the Lipinski rule. More synthetic, pharmacological, and structure-activity relationship (SAR) studies are needed to confirm their effectiveness in treating maturity-onset diabetes and elucidate their therapeutic utility further to enhance medicinal chemistry's hunt for life-saving medications.