EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF MESALAMINE BY GRBC STABILISATION ASSAY METHOD

Sruthi K., Fahida T., Faseela Thasni K. F., Nandana Unnikrishnan C. K.*

The objective of the study is to evaluate the anti-inflammatory potential of Mesalamine using the Goat Red Blood Cell membrane stabilization assay. Inflammation is a complex biological response to harmful stimuli and NSAIDs play a crucial role in managing inflammatory conditions. In this study, the GRBC membrane stabilization assay was employed to assess the protective effect of Mesalamine against hypotonic stress-induced hemolysis. The percentage membrane protection and percentage hemolysis were calculated to determine its stabilizing effect. The results demonstrated significant membrane stabilization activity, indicating that Mesalamine effectively prevents RBC lysis and helps maintain membrane integrity under inflammatory conditions. This study provides valuable insights into the anti-inflammatory mechanism of Mesalamine and supports its therapeutic role in inflammation management.