DESIGN AND EVALUATION OF DIVERSE MICROSPHERE TYPES UTILIZING OLMESARTAN AND VALSARTAN FOR HYPERTENSION MANAGEMENT

J. Praveen Kumar*, Manikandan A. and Dr. D. Jothieswari

The objective of the current study is to construct and evaluate, in vitro several types of microspheres containing olmesartan and valsartan to improve bioavailability and extend gastric residence duration, hence enhancing patient compliance through reduced dose frequency. All the formulations are prepared by Ionotropic gelation method using Sodium alginate and various natural polymers. We made an attempt to prepare normal, floating and mucoadhesive microspheres using Gelation technique with natural hydrophilic and hydrophobic polymers. All the formulations exhibited good Preformulation properties and the results indicate that all are within the prescribed limits. From Olmesartan and Valsartan Floating microspheres formulations F14 was selected as optimized formulation. Invitro release study of formulation F14 showed 96% release after 12h in a controlled manner. Various kinetic models suggest that the drug release from floating microspheres was anomalous Non Fickian diffusion. FT-IR analyses confirmed the absence of drug-polymer interaction. The SEM of microspheres shows a hollow spherical structure with a rough surface morphology. The shell of microspheres also showed some porous structure it may be due to release of carbon dioxide. Optimized formulation F14 was selected for stability studies.