FORMULATION AND EVALUATION OF GARLIC ENTERIC COATED TABLET FOR NEURODEGENERATIVE DISEASE

Satheeshkumar P.*, Rajasekar S., Ramesh R., Ranganathan Y.

Garlic belongs to the Alliaceae family and has been known and used for centuries for medicinal purposes. Its sulfur compounds, enzymes, amino acids, and minerals contribute to its antibacterial, antifungal, antiviral, and antioxidant properties. This herb has been used as a prevention agent against cardiovascular diseases, cancer, and neurodegenerative diseases. The chemistry of garlic occurs by the conversion of alliin to allicin, which is responsible for its medicinal property. Extracts from garlic show inhibitory effects on various kinds of microorganisms such as bacteria, fungi, and viruses. Preparation of Tablets Various Methods Used in Tablet Manufacture: Wet Granulation, Dry Granulation, Direct Compression. Excipients Tablet Formulation: Diluents, Binders, Glidants, Lubricants, Disintegrating agents, Colouring agents and antiadherents. Neurodegenerative diseases are a type of disease characterized by progressive neuronal loss in the central nervous system, for example, Alzheimer's and Parkinson's diseases. Neuroprotective effects have been attributed to garlic, which could help in preventing or treating such diseases.