A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV METHOD FOR VILDAGLIPTIN

Saad Javed Shaikh* and Swapnil Daunde

The present study describes the development of a new rapid, simple, sensitive and reproducible UV Spectrophotometry RP-HPLC, HPTLC method for the analysis of Vildagliptin that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. Vildagliptin is an antidiabetic agent, belongs to the dipeptidyl peptidase IV (DPP-4) inhibitors. The method employs measurement of absorbance at the wavelength of maximum absorptions of vildagliptin using water as a solven. In order to develop a RP-HPLC, HPTLC, UV effective most of the effect should be spent in method development and optimization as this will improve the final method performance. A well- developed method should be easy to validate. Review of literature on drug strongly indicates that there is few methods available for determination and validation of vildagliptin in bulk and pharmaceutical dosage forms.