REAL TIME DRUG STABIITY MONITORING IN PACKAGING MATERIAL

Prashik Chopade*, Siddhant Satpute and Roshan Kamble

Real-time drug stability assessment utilizes non-invasive techniques to evaluate the quality of pharmaceutical products without opening their packaging. Methods such as Infrared (IR) and Ultraviolet (UV) spectroscopy, along with temperature monitoring via embedded non-invasive sensors, enable the detection of chemical or physical changes in the drug. These spectroscopic techniques are particularly effective in distinguishing between expired and stable formulations, offering critical insights into drug integrity and potency. The primary advantage of real-time monitoring is its ability to ensure consistent drug stability, efficacy, and patient safety. This review explores the evolution of advanced stability monitoring technologies, including biosensors, RFID tags, and smart packaging systems that provide continuous environmental data. These innovations contribute to improved pharmaceutical reliability, enhanced transparency across the supply chain, and strengthened patient safety. In addition, the review discusses the challenges and future directions of real-time monitoring, such as regulatory compliance, economic feasibility, and integration with current packaging systems. Embracing these intelligent monitoring solutions enables the pharmaceutical industry to enhance the precision of stability evaluations, minimize quality-related product losses, and maintain drug efficacy throughout the product’s lifecycle.