OVERVIEW ON: NASAL DRUG DELIVERY SYSTEM

Swarupa P. Thavare*, Saloni Narkhaedkar, Sakshi Kapre, Sakshi Kamble, Pranita Kumbhar, Aditi Thakur and Preeti Zadake

Nasal administration of medicines has been used for both therapeutic and recreational purposes since ancient times. In recent decades, the systemic effects of medications delivered via the nasal route have attracted increased attention and significance. Nasal drug delivery has been explored as a promising alternative for administering vaccines and biomolecules, including proteins, peptides, and non-peptide drugs.The nasal cavity offers several advantages for systemic drug delivery due to its high permeability, rich vascularization, low enzymatic activity, and the ability to bypass hepatic first-pass metabolism. Because of its extensive vascular network and high permeability, the nasal mucosa allows for rapid absorption and fast onset of action. Moreover, the nasal route presents a long-term, viable alternative to parenteral therapy. It has also been successfully employed to deliver drug molecules directly to the central nervous system (CNS) by bypassing the blood-brain barrier (BBB), opening new possibilities for treating neurological conditions.