THERAPEUTIC POTENTIAL OF SARGASSUM WIGHTII: A STUDY ON ITS ANTIMICROBIAL AND ANTICANCER EFFECTS

S. Justin Raj*, Ajin A. M., Akshay J. S., Kishore Zen S. S. and Salman Hassan F. S.

Sargassum wightii is brown algae growing in tropical and sub tropical regions have been known for a wide range of biological activities. It can produce a large number of secondary metabolites and is a rich source of potential plant-derived by-products with antiviral, antihelminthic, antifungal, antibacterial, and antitumor properties. The current study examined the antibacterial and antitumor properties of Sargassum wightii's crude methanolic extract in vitro. The disc diffusion method was used to measure the antibacterial efficacy. Streptococci with aqueous extract had the highest antibacterial activity, measuring 11 mm, while Klebsiella with methanol, acetone, and aqueous extracts had the lowest activity, measuring 7 mm. The results demonstrated the bioactives' significant antibacterial activity against bacterial infections that affect humans. According to preliminary screening, the methanol extract of S. wightii reduced the proliferation of the human hepatocellular adenocarcinoma cell line (HepG2) with 9.35% of cell viability in E-200mg at IC50-60 mg/ml and the human dermal fibroblast cell lines (HDF) with 72% cell viability. Additionally, the superior antibacterial and antitumor properties demonstrated that Sargassum wightii, a sea algae, possesses superior properties for a variety of infections.