A REVIEW ON GASTRO RETENTIVE DRUG DELIVERY: STRATEGIES FOR PROLONGED GASTRIC RETENTION

*Shashikant D. Modekar, Sujit T. Karpe, Krishna R. Kudale, Abhishek B. Ghalke, Sanika S. Survase, Sanjyot S. Kasture and Vishwambhar A. Vhatkar

The potential of gastro retentive drug delivery systems (GRDDS) to improve patient compliance and therapeutic efficacy by extending stomach residence time and improving drug release kinetics has attracted much attention recently. This review offers a thorough summary of the most recent developments in GRDDS, emphasizing formulation tactics, design tenets, and assessment techniques. A detailed discussion of several strategies is given, emphasizing their modes of action and uses in targeted drug delivery, including floating, Mucoadhesive, expandable, and magnetic systems. Furthermore, new GRDDS with enhanced stability, controlled release profiles, and biocompatibility have been made possible by recent advancements in formulation technologies and materials science. The paper also discusses the difficulties that come with GRDDS, such as medication stability, physiological variability, and regulatory issues, and suggests possible solutions. Furthermore, the clinical applicability of GRDDS in the management of different gastrointestinal conditions and their potential use in targeted therapy and personalized medicine will be examined. The overall goal of this study is to offer insightful information on the state-of-the-art in GRDDS research at the moment and how it relates to the development of drug delivery technology.