A NOVEL POLYHERBAL GEL CENTELLA ASIATICA AND ACACIA ARABICA APPROACH FOR WOUND HEALING AND SKIN PENETRATION

*Anil Kumar Manhar, Deepesh Lall, Ritesh Jain, Abhinay Dehre, Ruchika Chandrakar, Syed Saif Ullah

The current research was undertaken to develop and evaluate a novel polyherbal phytosomal gel utilizing ethanolic extracts of Centella asiatica and Acacia arabica, with the objective of enhancing wound healing efficacy through improved dermal delivery and bioavailability of phytoconstituents. Initial standardization involved comprehensive physicochemical and qualitative phytochemical analyses of the crude plant materials and their respective ethanolic extracts to confirm identity, purity, and presence of bioactive markers. Polyherbal phytosomes were formulated using the thin-layer hydration method and subsequently optimized for critical formulation parameters including vesicle size, zeta potential, and entrapment efficiency. The optimized phytosomal dispersion was incorporated into a topical gel base using Carbopol 934, and the final gel formulation was evaluated for organoleptic properties, pH, viscosity, spreadability, and homogeneity. In adittion, in vitro diffusion studies, anti microbial activity studied conduceted. The findings suggest that the developed polyherbal phytosomal gel offers a scientifically validated, effective, and stable wound healing formulation with potential for clinical application.