A RESEARCH ON COMPARATIVE DISSOLUTION STUDY, STABILITY TESTING AND WEIGHT VARIATION OF 5 BRANDS OF AMOXICILLIN TRIHYDRATE 500mg CAPSULE USING UV SPECTROSCOPY

Sachin Pandey, Abhishek Bhardwaj*, Krati, Dr. Esha Vatsa and Dr. Amandeep Singh

Five commercial brands of 500 mg amoxicillin capsules Torrvis, Alkem, Lupin, Skymap, and Abbott are compared in this study with an emphasis on weight variation, dissolving profile, and stability testing using UV-visible spectroscopy.[1] Distilled water was used as the dissolve medium in the dissolution investigations, and a UV spectrophotometer was used to measure the drug release at 272 nm.[7] under order to evaluate short-term deterioration, stability testing was carried out over a 24-hour period under ambient circumstances. Weighing 20 capsules from each brand separately allowed us to assess weight variance. All five brands met pharmacopeial limitations for weight variance, according to the data. According to dissolution trials, Abbott and Alkem had somewhat quicker release rates, however all brands released more than 85% of the medication in 60 minutes, demonstrating good bioavailability.[5,12,26] After a day, stability testing showed that Skymap and Torrvis had significantly degraded, while Alkem had stayed the most stable. According to the study's findings, UV spectroscopy is a useful technique for evaluating the drug content, dissolving pattern, and short-term stability of amoxicillin capsules, and all brands are pharmaceutically acceptable.[1,4]