A SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF PANTAPRAZOLE IN BULK AND MARKETED FORMULATION

*D.Chinababu, Vishal Bharat Babar, *Kamble Sanika, Yadav Manisha, Sorate Akanksha, Kangude Siddhi, Shingate Sonali, SK. Aleesha

Pantaprazole was estimated using a straightforward, sensitive, and selective UV approach that was devised and verified. The technique was developed using UV spectrometry; the optimal concentration was 10µg/ml, the absorbance was 0.449, and the λmax was reached at 292nm with solvent water: ethanol (8:2 V/V). The linearity range of the test technique was 0.5 µg/ml to 16 µg/ml, which had an R2 value of 0.999. It was discovered that the accuracy % assay 98.64-99.96%. The results indicated that the intraday precision and interday precision % RSD values were found in between 0.32 -0.52. The developed method's LOD and LOQ were 0.15µg/ml and 0.44 µg/ml respectively. The robustness results were found to be 99.72%-101.78% for wavelength variation and organic phase change.