HOLISTIC PERSPECTIVES ON PCOS: A REVIEW ON MEDICINAL PLANTS

Akula Sowjanya*, B. Deepika, J. Kavya, K. Poojitha, E. Mahima

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that affects 5-16% of women of reproductive age, leading to symptoms like irregular menstruation, anovulation, hyperandrogenism, and infertility. This review examines the pathophysiology, symptoms, and managing PCOS, based on data from sources like Science Direct, NIH, and Google Scholar. The disorder is multifactorial, influenced by genetic predisposition and environmental factors such as diet, stress, and exposure to environmental pollutants. Internal factors like insulin resistance, obesity, oxidative stress, and inflammation also contribute to its development. The pathophysiological mechanisms of PCOS involve disrupted hormonal signaling and altered follicular development. Management approaches focus on improving insulin sensitivity, regulating ovulation, and reducing hyperandrogenism. Lifestyle modifications, including dietary changes, exercise, and yoga, are considered first-line therapies, while hormonal treatments like metformin and clomiphene citrate are commonly prescribed. Additionally, medicinal plants such as Mangifera, cinnamon, and Vitex agnus-castus, etc. May help manage PCOS symptoms, though they should complement, not replace, conventional treatments. Methodologically, the review synthesizes findings from literature on PCOS pathogenesis and treatments and presents an integrated approach combining lifestyle changes, medications, and herbal remedies. Early diagnosis and holistic management are essential to improving fertility outcomes and overall health in women with PCOS. This review underscores the need for ongoing exploration of effective treatment, emphasizing personalized care approaches.