ADVERSE DRUG REACTIONS AND DRUG INTERACTIONS OF TAXANES

Milin Thomas*, Dr. Sreejith K., Vismaya M. V., Shabeeba O. P., Lubina Sahnas

Paclitaxel and docetaxel are key chemotherapy agents for various cancers, but their use is often limited by adverse drug reactions (ADRs) and drug–drug interactions. A review of clinical and pharmacokinetic studies was performed to identify major ADRs and interaction mechanisms. Adverse drug reactions of taxanes frequently include neutropenia, peripheral neuropathy (worsened by cumulative dosing), hypersensitivity (linked to solvents Cremophor EL and polysorbate 80), alopecia, mucositis, and GI upset. Both drugs are metabolised by CYP3A4 and CYP2C8. CYP inhibitors can raise toxicity risk; inducers may reduce efficacy. The timing of taxanes with agents like cisplatin or anthracyclines also impacts toxicity and effectiveness. Effective use of taxanes requires vigilant monitoring, personalised dosing, premedication, and awareness of interactions. These strategies help maximise efficacy and minimise harm.