A SYSTEMATIC REVIEW ON BERBERINE-LOADED SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS: ADVANCES AND FUTURE PERSPECTIVES

 Ajaz Alam*, Ran Vijay Singh and Dr. Sanjay Kumar Kushwaha

The bioactive isoquinoline alkaloid berberine, which is derived from a variety of medicinal plants, has shown promise pharmacologically, with anti-inflammatory, antibacterial, antidiabetic, and anticancer properties. Its significant first-pass metabolism, low oral bioavailability, and poor water solubility, however, restrict its clinical use. In order to improve the solubility, stability, and absorption of berberine, Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) have become a viable approach. With a focus on important formulation elements, production techniques, in vitro and in vivo assessments, and pharmacokinetic improvements, this systematic review critically assesses the most recent developments in the creation of berberine-loaded SNEDDS.[1] The paper also looks at the significance of lipid-based carriers in targeting particular tissues and highlights the mechanistic insights into SNEDDS-mediated absorption enhancement. Concerns about regulations, scalability, and formulation stability are additional difficulties.