EVALUATION OF ANTI-ARTHRITIC, THROMBOLYTIC, AND ANTI-INFLAMMATORY ACTIVITIES OF GLYCOSMIS PENTAPHYLLA (RETZ.) DC

Md. Enamul Haque*, Dr. Md. Sohel Rana, and Dr. Md. Akbar Hossain

The present study evaluates the anti-arthritic, thrombolytic, and anti-inflammatory potential of various solvent fractions of Glycosmis pentaphylla (Retz.) DC. Phytochemical screening revealed the presence of flavonoids, alkaloids, phenolics, and tannins. The anti- arthritic activity was assessed by protein denaturation assay, thrombolytic activity was measured using a clot lysis assay, and anti-inflammatory activity was tested using egg albumin denaturation method. Among all fractions, the chloroform soluble fraction (CHSF) exhibited the most promising results with 82.56% inhibition of protein denaturation, 48.27% clot lysis, and 74.23% inhibition of albumin denaturation at 500 μg/mL. These findings support the ethnomedicinal use of G. pentaphylla and suggest its potential for development as a natural therapeutic agent.